Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae.
DNA methylation is an important epigenetic mechanism for phenotypic diversification in all forms of life.We previously described remarkable cell-to-cell heterogeneity in epigenetic pattern within a clonal population of Streptococcus pneumoniae, a leading human pathogen.We here report that the epigenetic diversity is caused by extensive DNA inversio